Epigenetic signature changes in low oxygen levels may contribute to prostate cancer development

October 29, 2015

Epigenetic alterations were also identified across the extent of the genome and involved increased histone acetylation and DNA methylation. These epigenetic processes may promote and maintain the expression of regulatory genes and activation of adaptive pathways that possibly promote tumour development.

Commenting on the significance of the findings, Dr Jenny Watson, a Health Research Board North/South funded postdoctoral scientist and lead author on the publication, said, ???Understanding how chronic hypoxia influences global and gene-specific epigenetic programming will provide important insights into the mechanisms of hypoxia-induced cellular changes. The identification of these factors contributing to the initial development of prostate cancer represents important targets for early detection and manipulation in early stage disease???.

This research was funded by the Health Research Board in Ireland [HRB NS/2004/2] and the UCD Horizon Scanning Seed funding scheme.