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How to choose a microarray service provider

April 22, 2016

Using two different Asian strains into which they inserted the E1-A226V mutation, they systematically added additional genetic portions from the African strain, followed by specific mutations to determine which interacted with E1-A226V. Then they tested each change to see whether it affected Aedes albopictus infectivity.Ultimately, they found that a single genetic element - which also changed an amino acid in the same envelope protein altered by the E1-A226V mutation - increased the Asian chikun...

Case Western Reserve launches new scientific and computational programs in Ohio

April 21, 2016

???The Biomedical Engineering Department and the Radiology Department have invested nearly $15 million in faculty recruitment and advanced imaging facilities that provide enviable research capabilities for exploring molecular, cellular, and organ structure and function at high resolution and in quantitative terms.???The Genetics department in the School of Medicine has invested several million dollars in bioinformatics and quantitative genetics programs.???The Biology department has established ...

Nano Terra, Kadmon sign deal to license novel product candidates

April 20, 2016

Commenting on the agreement, Samuel D. Waksal, Ph.D., Chairman and CEO of Kadmon, said: "Our development approach seeks to combine targeted drug candidates, acquired or internally developed, with innovative clinical strategies focused on sub-categories of disease, as determined by genetics, genomics, and other personalizing factors. This transaction brings to Kadmon remarkably well-developed clinical compounds targeting important pathways of disease as well as a powerful discovery engine, b...

Researchers temporarily turn off essential gene using RNAi technology

April 19, 2016

The shRNAs that targeted RPA3 were linked to a fluorescent tag. These were then used to generate transgenic mice in such a way that the team could trigger RNAi and shut off the RPA3 gene when the animals were fed a drug like tetracycline but not when the drug was withdrawn. The fluorescent tag allowed the scientists to easily monitor the tissues in which the target RPA3 gene had been switched off.When the scientists induced RPA3 suppression in adult mice, the animals' intestinal tissues rapidly ...

Insight into neurodegenerative diseases

April 18, 2016

In Freudenreich's study, the cell damage activated the Rad53 checkpoint kinase. But here, the protein arrested cell growth for an abnormally long period of time without repairing the damage. This often resulted in cell death. In cases where the cell did manage to recover and keep dividing, the researchers observed an increased frequency of repeat expansions. "The cells that were having trouble growing and dividing due to the expanded repeat accumulated additional expansions. It became a vic...